John L Butenhoff Selected Research

perfluorooctanoic acid

1/2014	Evaluation of perfluorooctanoate for potential genotoxicity.
8/2012	Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats.
10/2010	Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.
4/2010	Pathology Working Group review and evaluation of proliferative lesions of mammary gland tissues in female rats fed ammonium perfluorooctanoate (APFO) in the diet for 2 years.
6/2009	The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPARalpha).
6/2009	Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives.

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John L Butenhoff Research Topics

Disease

9	Hypertrophy 01/2018 - 07/2002
8	Body Weight (Weight, Body) 10/2017 - 07/2002
5	Hepatomegaly 03/2012 - 09/2008
4	Neoplasms (Cancer) 08/2012 - 07/2004
2	Liver Cell Adenoma (Hepatocellular Adenoma) 03/2012 - 07/2004
2	Hyperplasia 10/2010 - 06/2009
1	Inflammation (Inflammations) 01/2020
1	Weight Loss (Weight Reduction) 10/2017
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2014
1	Necrosis 07/2009
1	Atrophy 06/2009
1	Birth Weight (Birth Weights) 06/2009
1	Hepatocellular Carcinoma (Hepatoma) 07/2004
1	Hypothyroidism 07/2002

Drug/Important Bio-Agent (IBA)

7	CholesterolIBA 01/2018 - 07/2002
6	perfluorooctanoic acidIBA 01/2014 - 06/2009
5	Triglycerides (Triacylglycerol)IBA 01/2016 - 09/2008
5	PPAR alphaIBA 07/2009 - 07/2004
4	perfluorooctane sulfonic acidIBA 03/2012 - 06/2009
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 03/2012 - 07/2009
3	PotassiumIBA 03/2012 - 01/2008
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 10/2010
2	Ammonium CompoundsIBA 01/2014 - 04/2010
2	Thyroxine (Levothyroxine)FDA LinkGeneric 07/2012 - 01/2008
2	GlycogenIBA 03/2012 - 10/2010
2	pirinixic acidIBA 03/2012 - 10/2010
2	Estradiol (Delestrogen)FDA LinkGeneric 07/2004 - 07/2002
1	Amino Acids FDA Link 01/2020
1	Alkaline PhosphataseIBA 01/2018
1	Choline (Choline Chloride)IBA 10/2017
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	SaltsIBA 01/2014
1	Histidine (L-Histidine)FDA Link 01/2014
1	Tryptophan (L-Tryptophan)FDA Link 01/2014
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 01/2014
1	SodiumIBA 01/2014
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 07/2012
1	antineoplaston A10 (A 10)IBA 03/2012
1	DNA (Deoxyribonucleic Acid)IBA 03/2012
1	Alanine Transaminase (SGPT)IBA 03/2012
1	Cytochrome P-450 CYP4A (Alkane 1 Monooxygenase)IBA 03/2012
1	Acyl-CoA OxidaseIBA 03/2012
1	Cytochrome P-450 CYP3AIBA 03/2012
1	Fluorocarbon PolymersIBA 10/2010
1	Proteins (Proteins, Gene)FDA Link 10/2010
1	Cytochrome P-450 CYP2B1 (PROD)IBA 10/2010
1	Bromodeoxyuridine (BrdU)IBA 10/2010
1	Fatty Acids (Saturated Fatty Acids)IBA 07/2009
1	AlbuminsIBA 06/2009
1	Drinking WaterIBA 06/2009
1	Surface-Active Agents (Surfactants)IBA 09/2008
1	perfluorooctaneIBA 09/2008
1	Peroxisomal Bifunctional EnzymeIBA 07/2004
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2004
1	perfluorooctanesulfonamideIBA 07/2004
1	Peroxisome ProliferatorsIBA 07/2004
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2004
1	LipidsIBA 07/2002
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 07/2002

Therapy/Procedure

1	Intravenous Injections 01/2008